Exploration of DAPI analogues: Synthesis, antitrypanosomal activity, DNA binding and fluorescence properties
نویسندگان
چکیده
منابع مشابه
Exploration of DAPI analogues: Synthesis, antitrypanosomal activity, DNA binding and fluorescence properties
The DAPI structure has been modified by replacing the phenyl group with substituted phenyl or heteroaryl rings. Twelve amidines were synthesized and their DNA binding, fluorescence properties, in vitro and in vivo activities were evaluated. These compounds are shown to bind in the DNA minor groove with high affinity, and exhibit superior in vitro antitrypanosomal activity to that of DAPI. Six n...
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ژورنال
عنوان ژورنال: European Journal of Medicinal Chemistry
سال: 2017
ISSN: 0223-5234
DOI: 10.1016/j.ejmech.2017.01.037